After repairs in the United States, the BRAINE returned to action in support of the invasion of the Philippines at Leyte Gulf. For the next seven months she supported invasions at Mindoro, Lingayen Gulf, Corregidor and Mindanao, successfully repelling attacks from kamikaze planes. On 1 December 1944, the BRAINE was assigned to Destroyer Squadron 23 -The Little Beavers. The night of 7 January 1945, as part of the destroyer screen for the convoy en route to the Lingayen Gulf landings, the BRAINE engaged and sank an enemy destroyer--the last surface engagement of World War II.
In May 1945 DesRon 23 was ordered to Okinawa as replacement picket ships. After being outfitted with new fire control radar, the BRAINE was assigned Picket Station No. 5 east of Okinawa, accompanied by the USS ANTHONY - DD515 and four LCS gunboats. Under constant attack by kamikaze planes, several were destroyed. On Sunday, 27 May 1945 the picket ships were attacked by four kamikaze planes. Two were shot down, but two hit the BRAINE in quick succession. The first crashed into No. 2 Handling Room which exploded. The plane's 500 pound bomb exploded in the Ward Room, wiping out the Medical Party and Combat Information Center. The second plane hit starboard amidships, wiping out the Damage Control Party, crashing through Sick Bay and Emergency Radio. Its bomb exploded in the boiler uptakes, rupturing a high pressure steam line and blowing the after stack overboard. Casualties resulted in 67 deaths and 102 wounded, the highest rate for a destroyer that did not sink. Men trapped on the bow and between the two fires were ordered to abandon ship. They were rescued by the four LCS gunboats and a plane from Rescue Squadron VH-3, but not before some were attacked by sharks.
After temporary repairs, the BRAINE returned to Boston for restoration, arriving on 6 August 1945. After restoration, the BRAINE was decommissioned on 26 July 1946 at Charleston, South Carolina and placed in reserve. For her service in World War II, the BRAINE earned nine battle stars. Her toll on the Japanese was a destroyer, six planes and six invasion supports. Her crew was awarded a Navy Cross, a Legion of Merit, five Silver Stars, a Navy and Marine Corps Medal, ten Bronze Stars, fourteen Commendation Ribbons and 187 Purple Hearts.
The USS BRAINE - DD630 was recommissioned in Charleston, South Carolina on 6 April 1951. She made two cruises to the Mediterranean with the Sixth Fleet as flagship of Destroyer Squadron 18, with ports of call at Gibraltar, France, Italy, Greece, Turkey, Yugoslavia, Monaco, Sicily and Portugal. In 1955 she was assigned to the Pacific Fleet and assisted in the evacuation of the Tachen Islands. The BRAINE was designated flagship of Destroyer Squadron 21 and made several Western Pacific cruises visting exotic places such as Hawaii, Japan, Okinawa, Korea, Taiwan, Philippines, Guam, Singapore, Hong Kong, Malaya and Australia. The BRAINE participated in extensive missions with the Seventh Fleet. In 1965-1967 the BRAINE was on duty with Task Force 77 on Yankee Station off Vietnam, supporting ground troops and disrupting enemy supply routes with shore bombardments. She participated in the first amphibious landing in Vietnam. On 4 November 1966 she was damaged a third time by enemy fire during a running gun battle with shore batteries, but suffered no casualties. While on plane guard duty with the carrier task force, she rescued several downed pilots. She weathered two Pacific typhoons requiring extensive repairs and causing the death of a sailor who courageously attempted repairs during extremely high seas. The BRAINE was commended for outstanding performance off North Vietnam and for overall excellence.